Tmem176a
WebTMEM176A is located in human chromosome 7q36.1, a region where there is a frequent loss of heterozygosity in human cancer [16, 17]. In our previous studies, the TMEM176A promoter was frequently methylated in human colorectal and esopha- geal cancers and served as a tumor suppressor in these cancers [18, 19]. WebMar 24, 2016 · Here we show that the intracellular ion channel TMEM176B and its homologue TMEM176A are strongly expressed in these RORγt (+) cells. We demonstrate that TMEM176A and B exhibit a similar cation channel activity and mainly colocalise in close proximity to the trans-Golgi network.
Tmem176a
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WebSep 9, 2024 · TMEM176A suppressed esophageal cancer cell growth both in vitro and in vivo. In conclusion, TMEM176A is frequently methylated in human ESCC and the expression of TMEM176A is regulated by promoter region methylation. TMEM176A methylation may serve as a diagnostic and prognostic marker in ESCC. TMEM176A is a potential tumor … WebTMEM176A is part of cluster 59 Proximal enterocytes - Transmembrane transport with confidence i Confidence is the fraction of times a gene was assigned to the cluster in …
WebNov 1, 2012 · Introduction. The transmembrane proteins TMEM176A and 176B belong to the CD20/Fc-ɛRIβ and membrane-spanning 4A (MS4A) family of proteins (Lurton et al., 1999, … WebTMEM176A is frequently methylated in human primary colorectal cancer, and methylation of TMEM176A is an independent prognostic factor for 5-year overall survival To analyze the methylation status of TMEM176A in colorectal cancer, 130 cases of primary human colorectal cancer samples and 8 cases of normal colorectal mucosa were used.
WebMay 25, 2010 · In addition, we showed that in using RNAi, these molecules are both involved in the maintenance of the immature state of the DCs. Taken together, these data suggest that Tmem176B and Tmem176A associate to form multimers and restrain DC maturation. Therefore, these two molecules may represent valid targets to regulate DC function. WebJul 4, 2016 · Six genes of interest: TMEM176A, TMEM176B, OLR1, FOSB, FAIM3 and MS4A1, chosen from the top genes based on their magnitude and significance of expression in nvAMD were tested (P < 0.05, log2 FC >...
WebMay 13, 2024 · TMEM176A and TMEM176B were two of the inflammasome-related genes that were significantly upregulated in patients responding to anti-PD-1, suggesting that they could function as a counter-regulatory mechanism in response to treatment. Similar findings were observed in the IPI-naive population . We then performed a paired analysis of tumor ...
WebNov 1, 2012 · Introduction. The transmembrane proteins TMEM176A and 176B belong to the CD20/Fc-ɛRIβ and membrane-spanning 4A (MS4A) family of proteins (Lurton et al., 1999, Zuccolo et al., 2010).Human TMEM176A was first identified from a screen of tumor-associated antigens in hepatocellular carcinoma (HCC) (Wang et al., 2002).However, … rain mlsWebJul 5, 2024 · Methylation of TMEM176A was associated with tumor metastasis (P<0.05) and was an independent prognostic factor for 5-year overall survival (OS) according to Cox proportional hazards model analysis (P<0.05). TMEM176A induced apoptosis and inhibited cell migration and invasion in CRC cells. TMEM176A suppressed CRC cell growth both in … rain mm/hWebMay 1, 2024 · While Tmem176a/bappeared surprisingly dispensable for 6 the protective function of Th17 and group 3 innate lymphoid cells (ILC3s) in the intestinal mucosa, we 7 found that they were required in cDCs for optimal antigen processing and presentation to CD4+T cells. 8 Using a real-time imaging method, we show that TMEM176A/B … rain mlpWebItem Tmem176a Mouse qPCR Template Standard (NM_025326) Company OriGene Technologies; Price Pricing Info Supplier Page View Company Product Page; Catalog Number MK200783; Quantity 1 kit; Type qPCR Template Standards; Target Tmem176a; Species Mouse; NCBI Full Gene Name transmembrane protein 176A; NCBI Gene Aliases … cvs nail clippersWeb微信公众号brainnew神内神外介绍：brainnews旗下，宣传神内和神外相关研究进展和资讯，服务神内和神外工作人员；Cell：微生物菌群通过触发免疫应答促进神经元修复再生 rain mm sydneyWebMethylation of TMEM176A sensitized H1299 and H23 cells to AZD0156, an ATM kinase inhibitor used to induce tumor cell death. Re-expression of TMEM176A reduced the … rain moneyWebSep 22, 2024 · TMEM176A and TMEM176B Are Candidate Regulators of Inhibition of Dendritic Cell Maturation and Function after Chronic Spinal Cord Injury. Study characterized Tmem176a and b expression in RORgamma t+ lymphocytes at transcriptional and protein levels and present evidence that both genes exert a redundant ion channel function … cvs muncie in tillotson