Plk1 function
Webb1 feb. 2024 · PLK1 plays multiple roles in the cell cycle: controls mitotic entry and the G2/M checkpoint, coordinates the centrosome and cell cycles, regulates spindle assembly and … Webb8 aug. 2024 · The same healing problem also happened when healthy mice received a drug that blocked the function of PLK1 protein. A closer look at the muscle satellite cells revealed the source of the problem. Without PLK1, the cells got stuck part way through their cell cycle, just before they were due to divide.
Plk1 function
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WebbUBAP2L-deficient cells exit mitosis and enter the next interphase in the presence of aberrant PLK1 kinase activity. The C-terminal domain of UBAP2L mediates its function on PLK1 independently of its role in stress response signaling. Importantly, the mitotic defects of UBAP2L-depleted cells are largely rescued by chemical inhibition of PLK1. Webb14 mars 2024 · Aurora kinase A (AURKA) is required for centrosome function and spindle assembly during mitosis that, once activated, phosphorylates Polo-like kinase 1 (PLK1) at Thr210 in presence of the co-factor Bora (82–85). PLK1 is the master regulator of the cell cycle, playing an important role in M-phase progression .
WebbKyung S Lee's 105 research works with 4,027 citations and 9,547 reads, including: Structural Optimization and Anticancer Activity of Polo-like Kinase 1 (Plk1) Polo-Box Domain (PBD) Inhibitors and ... WebbNational Center for Biotechnology Information
Webb4 apr. 2024 · PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt/beta-catenin signalling pathway. Non-mitotic functions of polo-like kinases in … WebbBackground and Purpose: Over the last decade, the inhibition of PLK1 has proven potent antiproliferative activity in vitro. However, the effectiveness of most synthetic targeted drugs has not yet been translated into clinics. Herein, we investigated the in vitro effects of two second-generation PLK1 inhibitors BI 6727 and GSK461364 in breast cancer cell …
WebbThe inhibitory activities of 16e on Plk1-PBD is >30-fold higher than those of PMQSpTPL. Both 16a and 16e possess excellent selectivity for Plk1-PBD over Plk2/3-PBD. Analysis of the cocrystal structure of Plk1-PBD in complex with 16a reveals that the 3-(trifluoromethyl)benzoyl group in 16a interacts with Arg516 through a π-stacking …
WebbNovember 2024. Cervical cancer is the fourth most frequently diagnosed and fatal gynecological cancer. 15–61% of all cases metastasize and develop chemoresistance, reducing the 5-year survival of cervical cancer patients to as low as 17%. Therefore, unraveling the mechanisms contributing to metastasis is critical in developing better … innotech excel consultingWebbIn this respect, our studies identified HBc as a PLK1 substrate in vitro, and mapped PLK1 phosphorylation sites on this protein. PLK1 is a proviral host factor that could be envisaged as a target for combined antiviral and anti-tumoral strategies against HBV infection and HBV mediated carcinogenesis. This article is protected by copyright. innotec high temp wachsWebb2 okt. 2024 · Specifically, PLK1 associated with spindle poles up to metaphase, but it relocalized to the equatorial plane, where spindle microtubules overlapped, as cells went through anaphase. Golsteyn et al. (1995) concluded that PLK1 functions in mitotic cells to control spindle dynamics and chromosome segregation. innotech integration groupWebbPlk1 appears to influence many aspects of airway smooth muscle function. For activation of airway smooth muscle cell proliferation, growth factor (i.e., platelet-derived growth factor or epidermal growth factor) stimulation results in phosphorylation of the Thr-210 site of Plk1 and subsequent activation of the MEK–ERK axis ( 5 ), which is essential to cell … innotech engineering consultWebbHowever, we find that Bora is restricted to the cytoplasm and that Plk1 is phosphorylated on T210 at the centrosomes. Our data demonstrate that while Plk1 activation occurs on centrosomes, downstream target phosphorylation by Plk1 first occurs in the nucleus. We discuss several explanations for this surprising separation of activation and function. innotech f companyWebb11 mars 2024 · The low mutation rate in the Plk1 gene is most probably due to the fact that Plk1 is an essential cell proliferation gene, therefore cells cannot handle the Plk1 loss of function. The first in vivo evidence showing that Plk1 can play as a tumor suppressor arose in 2008 with the first Plk1 genetic modified mice strain generated by gene-trapping … modern bedroom overhead light fixturesWebb9 juli 2008 · To understand when exactly PLK1 kinase activity is first induced during an ongoing cell cycle, we made use of a fluorescence resonance energy transfer (FRET) … innotech engineering calgary