Witryna12 gru 2024 · IMGN632 MONOTHERAPY IN FRONTLINE BPDCN. Poster Presentation, Abstract #1284. IMGN632, administered as a brief outpatient infusion, was evaluated as monotherapy in frontline BPDCN patients. Three patients received IMGN632 prior to commencement of the enrolling pivotal cohort and achieved a clinical complete … Witryna1 wrz 2024 · Context. IMGN632, a novel CD123-targeting ADC, demonstrates a favorable safety profile and complete remissions as a monotherapy in patients with relapsed/refractory AML and BPDCN (NCT03386513).In pre-clinical models, IMGN632 has been shown to be synergistic with venetoclax (BCL-2 inhibitor) (EHA, 2024, …
ImmunoGen Presents Updated Findings from Phase 1 Study of IMGN632 …
Witryna5 lis 2024 · IMGN632 is a CD123-targeting antibody-drug conjugate (ADC) comprising a novel anti-CD123 antibody coupled, via a highly-stable peptide linker, to a unique DNA-alkylating cytotoxic payload of the recently developed IGN (indolinobenzodiazepine pseudodimer) class. Preclinically, IMGN632 has demonstrated potent activity against … WitrynaMenu. Stanford Medicine Explore Stanford Medicine. Health Care . Find a doctor; Adult-care doctor; Pediatrician or pediatric specialist tryptophan catabolism
IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine …
Witryna4 lis 2024 · ImmunoGen, Inc. IMGN reported loss of 15 cents per share for the third quarter of 2024, narrower than the Zacks Consensus Estimate of a loss of 19 cents and the year-ago loss of 31 cents. The loss ... Witryna29 gru 2024 · A Phase 1/2, Multi-center, Open-label Study of IMGN632 Monotherapy Administered Intravenously in Patients With CD123-positive Acute Myeloid Leukemia … Witryna25 lut 2024 · IMGN632 is an anti-CD123 ADC with a novel DNA-alkylating IGN (indolinobenzodiazepine pseudodimer) payload and a cleavable peptide linker. ... Sweet KL, et al. A phase Ib/II study of the CD123-targeting antibody-drug conjugate IMGN632 as monotherapy or in combination with venetoclax and/or azacitidine for patients with … tryptophan cas number